王磊 博士生导师

职称：教授

最高学位：博士

电话：13943085518

Email：w_lei@jlu.edu.cn

工作地点：生命科学楼279

微信公众号：JLU酶促有机合成

研究方向：1、酶促绿色有机合成

     2、酶催化非天然反应

     3、酶分子改造以及定向进化

教育经历：1997-2001：公司大学化学学院化学专业，获理学学士学位

2001-2006：公司化学学院有机化学系，获理学博士学位

工作经历：2006 -2008：公司分子酶学工程教育部重点实验室担任讲师

2008-2014：公司分子酶学工程教育部重点实验室任副教授

2014-现在：公司分子酶学工程教育部重点实验室任教授

2012-2013：美国阿克伦大学化学系，访问学者

研究成果：[1] Yaning Xu, Fengxi Li, Nan Zhao, Jiali Su, Chunyu Wang, Ciduo Wang, Zhengqiang Li* and Lei Wang*, Environment-friendly and efficient synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles catalyzed by Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor,Green Chem., 2021,23, 8047-8052. IF: 10.182.

[2] Fengxi Li, Xuyong Tang, Yaning Xu, Chunyu Wang, Zhi Wang, Zhengqiang Li,* Lei Wang*.A Dual-Protein Cascade Reaction for the Regioselective Synthesis of Quinoxalines;Org. Lett.,2020, 3900-3904. IF: 6.555.

[3] Fengxi Li, Yaning Xu, Ciduo Wang, Chunyu Wang, Ruihong Zhao* and Lei Wang*, Efficient Synthesis of Cyano-containing Multi-substituted Indoles Catalyzed by Lipase,Bioorg. Chem., 2021, 107, 104583. IF:5.275.

[4] Fengxi Li, Chunyu Wang, Yaning Xu, Zixian Zhao, Jiali Su, Chenhan Luo, Yujie Ning, Zhengqiang Li, Chen Li* and Lei Wang*, Efficient synthesis of unsymmetrical trisubstituted 1,3,5-triazines catalyzed by hemoglobin,Mol. Catal., 2021, 505, 111519. IF:5.062.

[5] Fengxi Li, Jiali Su, Yaning Xu, Jiaxu Liu, Yue Yu, Chunyu Wang, Zhengqiang Li, Chen Li and Lei Wang, A glucoseoxidase-hemoglobin system for efficient oxysulfonylation of alkenes/alkynes in water,Mol. Catal., 2021, 500, 111336. IF:5.062.

[6] FengxiLi, Zhengqiang Li, Xuyong Tang, Xinyu Cao, Chunyu Wang, Jialin Li, Lei Wang*, Hemoglobin: a new biocatalyst for the synthesis of 2-substituted benzoxazolesvia oxidative cyclization,ChemCatChem, 2019, 11(4), 1192-1195. IF：4.647.

[7] Fengxi Li, Xuyong Tang, Yaning Xu, Chunyu Wang, Liu Zhang, Jiaxin Zhang, Jiaxu Liu, Zhengqiang Li,* Lei Wang*, Hemoglobin-Catalyzed Synthesis of Indolizines Under Mild Conditions.Eur. J. Org. Chem., 2019, 7720-7724. IF:3.029.

[8] Jiaxu Liu, Fengxi Li, Xin Zheng, Jiali Su, Yue Yu, Lei Wang*, Hong Zhuang*, Lipase-catalyzed synthesis of polyhydroxyalkyl furans from unprotected sugars and malononitrile, Process Biochem., 2021, 101, 99-103. IF: 3.757.

[9] Jiaxin Zhang, Ciduo Wang, Chunyu Wang, Wei Shang, Bao Xiao, Songhan Duan, Fengxi Li, Lei Wang *, PengChen *. Lipase-catalyzed aza-Michael addition of amines to acrylates in supercritical carbon dioxid.J. Chem. Technol. Biotechnol.,2019, 3981-3986. IF: 2.659.

[10] Jiaxu Liu, Wenxin Zhao, Liu Zhang, Min Zhang, Yanqiang Chen, You Xu, Yinghua Li*, Lei Wang*, Synthesis of substituted 2H-chromenes catalyzed by lipase immobilized on magnetic multiwalled carbon nanotubes,Biotechnol. Appl. Biochem., 2021, 411-416. IF: 2.431.