研究成果 |
探究了溶酶体TMEM175钾离子通道调控帕金森病的分子机制,解析了Melatonin对外周组织生物钟节律和代谢的调节机制,在Nature、Journal of Pineal Research等杂志累计发表SCI论文20余篇,被引用1000余次。 代表性期刊论文: 1. Wie, J., Liu, Z., Song, H., Tropea, T.F., Yang, L., Wang, H., Liang, Y., Cang, C., Aranda, K., Lohmann, J., Yang, J., Lu, B., Chen-Plotkin, A.S., Luk, K.C. and Ren, D. A potassium channel in lysosomes regulates Parkinson’s pathology. Nature. (2021): 1-7. https://doi.org/10.1038/s41586-021-03185-z 2. Liu Z., Gan L., Zhang T., Ren Q., Sun C. Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice. Journal of Pineal Research. 2018 Jan;64(1). doi: 10.1111/jpi.12455 3. Liu Z., Gan L., Xu Y., Luo D., Ren Q., Wu S., Sun C. Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue. Journal of Pineal Research. 2017 Aug;63(1). doi: 10.1111/jpi.12414. 4. Liu Z., Gan L., Luo D., Sun C. Melatonin promotes circadian rhythm-induced proliferation through interaction of Clock/HDAC3/c-Myc in mice adipose tissue. Journal of Pineal Research. 2017 May;62(4). doi: 10.1111/jpi.12383. 5. Liu Z., Gan L., Wu, T., Feng, F., Luo, D., Liu, S., Sun, C. Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Cell Death and Disease. 2016 Nov 24;7(11): e2487. doi: 10.1038/cddis.2016.388.
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